| Chineses Pinyin | JiaoGuLan | ||
| Habitat | SiChuan, YunNan, HuBei, HuNan, GuangDong, GuangXi, Shaanxi, FuJian | ||
| Flavor | Bitter; Slightly Sweet | ||
| Meridian Tropism | Lung; Spleen; Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Cucurbitales
-->Family: Cucurbitaceae
-->Genus: Gynostemma
-->Species: Gynostemma pentaphyllum
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| Pair Name | Gynostemma Extract, Fluorouracil | |||
| Partner Name | Fluorouracil | |||
| Disease Info | [ICD-11: 2B91.Z] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Up-regulation | Phosphorylation | TP53 | hsa7157 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| Up-regulation | Phosphorylation | H2AX | hsa3014 | |
| In Vitro Model | SW480 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0546 |
| SW620 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0547 | |
| Caco-2 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0025 | |
| In Vivo Model | Three mice were used as normal control, all others were inoculated with 0.1 ml of CT-26 cells (1×10⁷ cells/ml) into the left oxter region and randomly divided into 6 groups with 6–8 animals in each group. | |||
| Result | Gypenosides Synergistically Enhances the Anti-Tumor Effect of 5-Fluorouracil on Colorectal Cancer In Vitro and In Vivo: A Role for Oxidative Stress-Mediated DNA Damage and p53 Activation | |||
